Hydroxysteroid dehydrogenase

The Hydroxysteroid dehydrogenases are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids.

There are four types, classified by the number of the carbon acted upon:

Carbon	From	To
3	pregnenolone	progesterone
3	17-Hydroxypregnenolone	17-Hydroxyprogesterone
3	dehydroepiandrosterone	androstenedione
11	cortisol	cortisone
17	androstenedione	testosterone
20	progesterone	20-alpha-dihydroprogesterone

See also

steroid hydroxylases

Additional images

External links

MeSH Hydroxysteroid+Dehydrogenases

Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1: NAD/NADP acceptor	Alcohol dehydrogenase · Aldo-keto reductase (1A1, 1B1, 1B10, 1C1, 1C3, 1C4, 7A2) · Aldose reductase · Carbohydrate dehydrogenases · Carnitine dehydrogenase · DXP reductoisomerase · Glucose-6-phosphate dehydrogenase · Glycerol-3-phosphate dehydrogenase · HMG-CoA reductase · 3-hydroxyacyl-CoA dehydrogenase · Beta-hydroxybutyryl-CoA dehydrogenase · Isocitrate dehydrogenase · IMP dehydrogenase · Β-Ketoacyl ACP reductase · Lactate dehydrogenase · Malate dehydrogenase · Phosphogluconate dehydrogenase · L-threonine dehydrogenase · L-xylulose reductase · Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3 Beta (3-beta-HSD, NSDHL) · 11 Beta (HSD11B1, HSD11B2) · 17 Beta

1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) · D-lactate dehydrogenase (cytochrome c-553) · Mannitol dehydrogenase (cytochrome)

1.1.3: oxygen acceptor	Glucose oxidase · L-gulonolactone oxidase · Xanthine oxidase

1.1.4: disulfide as acceptor	Vitamin K epoxide reductase · Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5: quinone/similar acceptor	Quinoprotein glucose dehydrogenase

1.1.99: other acceptors	Choline dehydrogenase · L2HGDH

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase · Geranyl pyrophosphate

To lanosterol	Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase

Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase

Steroidogenesis

To pregnenolone

Side-chain cleavage

To corticosteroids

aldosterone: 18-hydroxylase

cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2)

both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase

To sex hormones

To androgens	17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase (1,2)

To estrogens	Aromatase

Other/ungrouped

Steroid metabolism: sulfatase (Steroid sulfatase) · sulfotransferase (SULT1A1, SULT2A1)

Steroidogenic acute regulatory protein

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)